April 2025 Updates - The Bioentrepreneurs: Stanford

As part of their mission to develop a playbook for discovering allostery, begun assaying their second large-scale enzyme mutant library. Their first large-scale library demonstrated that QUIKER (QUantitative In vitro Kinetics of parallel Enzyme Reactions) allosteric site discovery platform can successfully identify both novel and known allosteric sites, validating the platform’s ability to map functional surfaces at scale.

Made major strides in developing their DASH (Directed Affinity Selections with High throughput microfluidics) site-selective hit identification platform by increasing the parallelization capacity of its library-on-library DEL assays. Leveraging DASH, recapitulated known mutational effects on binding and discovered new residues that are coupled to binding as they continue to scale up and refine their capabilities.

Unveiled its lead tumor-targeted drug conjugate and new radiopharmaceutical program at debut scientific presentation

Welcomed Joy Geallis, Head of Clinical, to the TwoStep Team!

Yash Agarwal, PhD, promoted to Director, R&D Operations

Now offering custom compounded prescriptions for acne, wrinkles, hair loss, hyperpigmentation/melasma, rosacea, and more that are 50% more bioavailable and 2x more hydrating than competitors. Available to dermatologists and patients via telehealth.

Published paper in Dermatologica Helvetica on the promise of Skin Microbiome Testing and Bacteriophage Therapy

Selected as a pitch finalist by L'Oréal to present at Dermatology Beauty Connect in Miami

Discount code available to The Bioentrepreneurs community for 20% off with BIO20ENTREPRENEUR (expires 4.30.25)

Announced research collaboration and option agreement with Daiichi Sankyo to develop cell-targeted RNA medicines

Entered into strategic collaboration with Johnson & Johnson for the design and development of cell-targeted delivery vehicles

Announced a new website along with expansion of target indications beyond spine surgery into pain management and interventional radiology

Completed filing of provisional patents on novel tracking technology

Completed first surgeon user evaluation session in March

First study with porcine models yielded impressive accuracy outcomes. Expecting to announce quantitative results within a few months.

"Can Humans Live to 150?" – CEO Alina Su shared insights on healthspan extension at the 2024 Fortune Brainstorm Health Conference

Speaking at HLTH 2024 – Highlighting longevity science and preventative care in this conference clip

SystemAge™ Platform Adoption – Now used by nearly 100 longevity clinics to track patient rejuvenation and optimize treatment intervals using biological age data

First White Paper Released – Covers biological age and aging speed across 19 organ systems; available on request via [email protected]. Endorsed by celebrity physicians including Dr. Adeel Khan (doctor to Tony Robbins, Zac Efron, and others)

"Why Biological Noise is a Sound You Can't Ignore" (Fortune Magazine) – Covered by major media outlets, including Fortune and Longevity.Technology

Featured in the documentary film Observer by Ian Cheney, which premiered at the NSTA Conference. The film explores the power of observation and features Foldscope co-creator Manu Prakash.

Attended two major science education conferences in March:

Posted a new preprint on MedRxiv: Octopi 2.0: Open and Scalable Microscopy Platform for AI-powered Diagnostic Applications

HIRING: Software engineer to accelerate development and meet growing demands from pharma and biotech. Reach out to

[email protected] for more detail.  

Selected as a grant awardee through the I-CREATE program by University Lab Partners, a BARDA Accelerator Network hub focused on medical devices and diagnostics. Will receive non-dilutive funding and support through the accelerator program to leverage their biomolecular recognition platform to build tools for better preparedness and response to health security threats.